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The prevalence of gallbladder cancer in gallstone patients is as low as 530 per 1000 patients, and most important risk factors for gallbladder carcinoma related to gallstone disease are gallstones, porcelain gallbladder (mostly if the gallbladder wall is partially calcified), large polyps of the gallbladder, and Mirizzi syndrome

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[15] Several variations of the basic structure exist, including backbones such as sphingosine in sphingomyelin, and hydrophilic groups such as phosphate in phospholipids

The glucose-dependent nature of their action reduces the risk of hypoglycemia compared to traditional diabetes medications