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Annu Rev Pharmacol Toxicol 37:397419 Aposhian HV, Gurzau ES, Le XC, Gurzau A, Healy SM, Lu X, Ma M, L Yip, Zakharyan RA, Maiorino RM, Dart RC, Tircus MG, Gonzalez Ramirez D, Morgan DL, Avram D, Aposhian MM (2000) Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic

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After manual exclusion of doublets and dead cells, t-stochastic neighbor embedding (t-SNE) analysis was applied to reduce dimensionality

With age, mGSH declines selectively, contributing to the mitochondrial dysfunction that underpins the "mitochondrial theory of aging." Restoring systemic GSH levels supports mGSH replenishment, with downstream effects on cellular energy production and biological aging rate