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Evidence for a general amino acid permease

That criticism is not the entire story

The reaction occurs at a given pH, and the reacting compounds are in equilibrium with this pH and thus giving off or receiving a proton has no effect on the energetics

This indicates serum sKlotho may not serve as a candidate marker for eGFR, but instead, as a possible marker for renal tubular damage, which may be another possible reason for the conflicting results