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At the end of the day, the option simply comes down to what youre looking to treat

For eligible adults with clinically significant obesity, MHRA-approved options include semaglutide (Wegovy, assessed in NICE TA875) and tirzepatide (Mounjaro, assessed in NICE TA1026), both available through NHS pathways with appropriate clinical oversight

Int J Mol Sci 24(21):15912 Xie L-k et al (2022) Capsella bursa -pastoris (L.) Medic

Retatrutide has shown common side effects similar to other GLP-1 receptor agonists, including: Nausea Vomiting Diarrohea Constipation Abdominal discomfort or bloating Some trial participants experienced a slight increase in resting heart rate, which has also been observed with other GLP-1 receptor agonists