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The safety and pharmacodynamic results in the multiple-dose trial must be interpreted in light of the high dose levels (2040 mg oral semaglutide) and the relatively fast initial dose escalation in this trial compared with the phase III trials, where dose levels of 314 mg oral semaglutide are investigated and a slower initial dose escalation is used to minimise gastrointestinal adverse effects

The 2.5mg starting dose is the initiation dose used in all SURMOUNT trials

Creatine should complement not replace the evidence-based nutritional framework recommended by BOMSS, NHS, and NICE guidelines

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