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It enhances neuronal survival, promotes angiogenesis and synaptic plasticity, and modulates key neurotransmitter systems, including dopaminergic, serotonergic, and GABAergic pathways

Recently, significant progress has been made in the field of rheumatoid arthritis (RA) drug treatment, mainly including biological agents and targeted synthetic drugs, such as TNF- inhibitors [37, 38] and specific intracellular signaling pathways inhibitors [39]

doi:10.1073/pnas.0308082100