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[16] Reported rates from trials include: Nausea: ~44% Vomiting: ~25% Diarrhea: ~31% Constipation: ~23% Dyspepsia: ~10% These effects reflect slowed gastric motility and are usually mild, but can lead to clinical implications: Dehydration Electrolyte abnormalities ED presentations for poor oral intake

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On the other hand, the Zepbound segment will show rapid expansion, due to its possession of GLP-1 and GIP receptor agonists are used in dual action, including in both glucose control and weight loss benefits, appealing to individuals with type 2 diabetes and those seeking weight management solutions