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Overall, ZFPG NPs mediated-ferroptosis/SDT effectively triggered the release and overexpression of DAMPs, potentially enhancing immune stimulatory or subverting immune suppressive effects through the activation of CTLs for sono-metallo-immunotherapy

Mutations of key driver genes in colorectal cancer progression and metastasis

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Approximately 40-50% of ER+ breast cancers harbor PI3KCA mutations, which are associated with increased GSH synthesis and resistance to oxidative stress, ultimately reducing the sensitivity of ER+ breast cancer to ferroptosis [21]