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Discussion We have previously shown that the GLP-1 component of cotadutide drives BW loss and improves metabolic homeostasis, while the glucagon action drives liver-specific benefits to reduce steatosis through inhibition of lipogenesis and improved mitochondrial function, accompanied by the critical downstream consequences of reduce inflammation and fibrosis 13 (Fig

Besides, other mammalian and non-mammalian small domestic animals like the guinea pig, hamster, rabbit, ferrets, birds, amphibians, fishes, flies, and worms have equal importance in terms of anatomical and physiological resemblance with humans