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Snapshot Proponents May help cleanse the bowels before medical procedures May relieve constipation Skeptics Most health claims are not backed by science The benefits from coffees active compounds are more effectively (and pleasantly) achieved by drinking it Used as part of fraudulent and expensive cancer therapies May cause digestive issues, bowel injuries, and electrolyte imbalances Use through History The first documented uses of coffee enemas for poisoning and post-operative care date back to the 19th century

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104,105 The activation of GLP-1R may enhance the brains capability to cope with stress by facilitating the release of neurotransmitters and managing the stress response, potentially mitigating both cognitive and emotional challenges related to aging