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A 2020 review in Diabetes Care noted that "the hypoglycaemic effect of IGF-1 has been exploited therapeutically in rare forms of insulin-receptor-defect syndromes, but the risk-benefit calculation differs fundamentally from use in euglycaemic individuals" [20]

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3 Thyroidbrain axis pathophysiology and neurological manifestations The major mechanistic routes linking thyroid dysfunction to neuropsychiatric manifestations are summarized in Figure 2, highlighting disrupted hormone transport/activation in the brain, neurotransmitter imbalance, oxidative stressneuroinflammation, and bloodbrain barrier vulnerability

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Since a dry, hacking cough is a frequent symptom of progressing MVD, this side effect of the drug could be confused with the worsening of the disease

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