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However, injectable vitamin B12, often prescribed to treat serious deficiencies, can cause the following side effects: mild diarrhea itching skin rash headache dizziness nausea vomiting pulmonary edema and congestive heart failure early in treatment vein thrombosis sensation of swelling polycythemia vera (rare, slow-growing blood cancer) Moreover, in rare cases, vitamin B12 can cause serious allergic reactions (anaphylaxis)

This is particularly critical if you take other medications

Genetic factors can influence Vitamin B12 metabolism, necessitating personalized dosing protocols

It's a compound with a well-established history in clinical trials, giving researchers a solid foundation of data to build upon, even as new avenues of inquiry emerge in 2026