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Because it works through cellular signaling rather than pharmacological action, the early-stage signals (reduced inflammation, calmer scalp) appear within the first few weeks but visible density change typically requires three to six months of consistent daily use

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Nature 380:435439 Henry TD, Annex BH, McKendall GR, Azrin MA, Lopez JJ, Giordano FJ, Shah PK, Willerson JT, Benza RL, Berman DS et al (2003) The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis

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