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The work had been conducted from March 2023 to March 2024 following approval from the Additional information Publishers note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations

PlexusDx charges a flat $189/month starting rate for semaglutide injection across all commitment tiers, meaning dose increases never trigger higher monthly costs

The research literature consistently describes DSIP as a sleep-promoting neuromodulator not a hypnotic or sedative agent with a modulating effect on sleep and wake functions that is most pronounced when sleep is disturbed, and minimal in healthy subjects without sleep disruption

Acknowledgements The authors would like to thank the Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES, Code 001), the National Council for Scientific and Technological Development and the Ministry of Healthy (CNPq/MS 444037/2023-3) for financial support