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Key Expert Opinions Sean Wharton, lead study author and medical director of the Wharton Medical Clinic, Canada, emphasized the clinical significance of the findings, stating that The STEP UP trial demonstrated that we can increase the dose of semaglutide and achieve greater weight loss than previously seen, and in line with semaglutide established safety profile

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David Ricks, Chair and Chief Executive Officer of Eli Lilly, noted that fewer than one in ten people who could benefit from a GLP-1 therapy are currently taking one, citing access barriers, stigma, and the complexity of existing treatment options

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