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Whether this translates to human risk is not established, but the medication is contraindicated in anyone with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

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This may be of benefit for anyone with MCAS, and clinical trials are looking at the effectiveness of different doses.[ref][ref] ( Related article: MCAS) Immune system modulation: The receptor for GLP-1 is found on the cell membrane of macrophages, regulatory T cells, and natural killer T cells

Dose Escalation : After the 4 weeks, the dose is increased incrementally, reaching doses of 5 mg, 10 mg, and potentially up to 15 mg weekly, depending on how the patient responds to the treatment (efficacy and tolerance)