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Regression analyses suggested that natural pregnancy was associated with weight loss and improvement in IR, indicating that the path from metabolic improvement to reproductive benefit is more likely driven by individual metabolic responses rather than by drug class alone (111, 112)

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ChaC2 enhances GSH production by upregulating Nrf2, a key regulator of antioxidation, and its downstream glutamate-cysteine ligase (78)

In addition, a -hairpin structure protrudes from the thumb toward the active site and is likely to be involved in correct positioning of the template 44