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This indicates a higher likelihood of absorption, a lower risk of active efflux, and reduced potential for interactions with Pgp inhibitors (see the Supporting Information: File S1)
In contrast, we found that these metabolomic alterations led to a reduction in the plasma level of different metabolites including uridine, thymine, carnosine, theophylline, aspartate, taurine, serine, glutamate, tryptophan, arginine, and 53 other metabolites in the acute patients compared to HCs ( Supplementary Figures 6A, B )
BPC 157 (10 g/kg, 10 ng/kg) was given immediately after NSAIDs administration, intraperitoneally (aspirin, diclofenac, paracetamol, ibuprofen, celecoxib) or intragastrically (aspirin, paracetamol) while controls received an equivolume (5 ml/kg) of saline