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Why Joint Aches Occur with B12 Supplementation When joint discomfort does arise in temporal association with vitamin B12 therapy, several possible explanations may be considered, though none represent a direct toxic or pharmacological effect of cobalamin itself

Proc Natl Acad Sci 103(12):43864391 Xin W, Feng S, Freisheim JH, Gentry LE, Ratnam M (1992) Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates

Because the gut cells themselves use it as fuel, much of the glutamine you ingest is utilized immediately in the digestive tract

and the National Institute of Health ( 1R01MH106563-01A1 (HFN, MCR)