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Transcriptional analysis of vitamin C-treated BEAS-2B cells, a bronchial epithelial cell line, found that pathways associated with antiviral activity were upregulated while pathways associated with lung injury, inflammation, oxidative stress were downregulated [84]

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The levels of HIF-1 and HO-1 were raised in diabetic kidney tissue exacerbated tubular iron accumulation, enhanced the lipid peroxidation response, and augmented the generation of ROS