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Due to its potential function in the occurrence and development of breast cancer, GPx2 is suggested as a potential target for the prevention and treatment of breast cancer

These CKD-related events happen through many different mechanisms, such as microbiome metabolites, weakened intestinal barriers, and changes in the neuroendocrine immune system ( IS is a uremic toxin that forms complexes with proteins

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Additionally, GPxs due to their subcellular compartmentalization (cytoplasmic, membrane, ER, and mitochondrial localizations) control the local concentration gradient of peroxides and thereby regulate the activation/deactivation of redox-responsive signaling pathways [1, 8,9,10]