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The dose should be achieved by titrating according to the following schedule: Adjunctive Therapy UseAdults (17 Years of Age and Over) - Partial Seizures, Primary Generalized Tonic-Clonic Seizures, or Lennox-Gastaut Syndrome The recommended total daily dose of topiramate as adjunctive therapy in adults with partial seizures is 200 to 400 mg/day in two divided doses, and 400 mg/day in two divided doses as adjunctive treatment in adults with primary generalized tonic-clonic seizures

On average, patients can expect to lose 5-10% of their initial body weight over six months, though some may experience more substantial results