studies provide compelling evidence that semaglutide use in orthopedic surgery is associated with lower rates of infection, readmission, and revision surgery, likely due to improved metabolic control, reductions in systemic inflammation, and weight loss-driven perioperative risk reduction
GLP-1 receptor agonists have been shown in multiple studies to exert anti-inflammatory effects, including inhibition of monocyte chemotaxis, suppression of macrophage inflammatory responses, and AMPK-mediated downregulation of the NF-B signaling pathway, thereby reducing systemic inflammation (36)
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For findings to be broadly applicable, the study population needs to reflect real-world patients in terms of age, gender, medical history, and dosing
