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Patients with a history of severe gastrointestinal disease, including gastroparesis, as tirzepatide can slow gastric emptying

People taking statins who might be able to reduce doses with weight loss

Cell Death Differ 14:12111221 Dieck ST, Heuer H, Ehrchen J, Otto C, Bauer K (1999) The peptide transporter PepT2 is expressed in rat brain and mediates the accumulation of the fluorescent dipeptide derivative beta-Ala-Lys-Nepsilon-AMCA in astrocytes

This suppression is the result of components in the extract inhibiting the rate-limiting enzyme of cholesterol biosynthesis HMG-CoA reductase (HMGR) as well as activating the potent metabolic regulatory enzyme AMP-activated kinase (AMPK)