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It is caused by either lack of intrinsic factors or surgical removal of parts of the digestive system that bypass the small intestine

J Biol Chem 110(3):665679 Ensafi AA, Rezaei B, Nouroozi S (2009) Flow injection spectrofluorimetric determination of cystine and cysteine

Comparing the Therapeutic Effectiveness of N-acetylcysteine with the Combination of N-acetyl Cysteine and Cimetidine in Acute Acetaminophen Toxicity: A Double-Blinded Clinical Trial