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Safety: Side-effect profiles are consistent with GLP-1 class medicines (nausea, GI symptoms), with tolerability similar to existing semaglutide treatments

However, most people develop lesions without any negative side-effects

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Individual case reports, pharmacovigilance signals, and post-marketing observations can raise concern about the worst vision side effects of Zepbound, but causality requires structured evaluation, including: Baseline incidence rates in relevant populations Confounder adjustment (diabetes, hypertension, sleep apnea, dyslipidemia) Temporal association and dechallenge patterns Mechanistic plausibility Consistency across datasets However, clinical prudence does not require perfect certainty before acting on a high severity signal