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EXAMPLE 2 The Target of AnglV Analogs is Hepatocyte Growth Factor This Example shows that the novel angiotensin IV ligand Dihexa and its parent molecule Nlel -AnglV act through the HGF/c-Met receptor system

contraindicated with personal/family history of MEN2 or medullary thyroid carcinoma Dose escalation principle / slow titration (4-week steps) reduces GI burden Key contraindication / personal or family history of medullary thyroid carcinoma or MEN2 syndrome Weight-loss benchmark / semaglutide 2.4 mg: 14.9% mean body weight loss at 68 weeks (STEP-1, N=1,961) Cardiovascular benefit / semaglutide reduced MACE by 20% vs