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Proc Natl Acad Sci Usa 2012;109:1464651

This erosion directly exposes colonic epithelium to luminal cytotoxic compounds and enteric pathogensincluding bacterial lipopolysaccharides (LPS) (Ijssennagger et al., 2015)

Senescence induction in colon (HTC116) and bladder (EJ) cancer cell lines, followed by an incubation with the B2M-ADC, led to the clearance of 35% of senescent cells