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By mimicking the functions of GIP and GLP-1, tirzepatide activates the receptors for these hormones in various organs and tissues, such as the pancreas, the digestive system, the central nervous system, and adipose tissue

Several studies using non-invasive physiological markers, such as reduced ABR wave-I amplitude, suggest an association between cochlear synaptopathy and tinnitus, particularly in individuals with normal audiograms 11,43,61,62

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perform the procedure under general anesthesia. Patients who consume a clear liquid diet on the day before the procedure, as is standard before a colonoscopy, do not need to hold the GLP-1 agonist just for the sake of decreasing risk of retained gastric contents, Shah noted