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It should be noted that the musculoskeletal evidence base remains preclinical, a 2025 scoping review by McGuire and colleagues in Current Reviews in Musculoskeletal Medicine found no adequately powered randomised controlled trials

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Use of semi-volatile chemicals, without further technical adjustments to prevent chemical cross-contamination (chemical creep), such as using adhesive seals on the testing plates is a confounding hazard that requires strict control, volatile chemicals generally need to be avoided in validation studies