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Compared with NRAS activating mutations at positions 12 and 13, NRAS Q61 mutations exert a stronger activating effect on the MAPK pathway since codon 61 is the catalytic residue for GTP hydrolysis and Q61 mutation impedes the return of RAS to an inactive GDP-bound state (92)

Compared to the ML model's performance metrics between 5-CV and independent validation, the Borderline-SMOTE techniques showed a minimal difference between 5-fold cross-validation (5-CV) and independent validation, but the overall results were suboptimal