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Cycle : 8-12 weeks (MK-677 up to 16 weeks)

Physical activity contributes significantly to total energy expenditure, which is determined by three primary components: basal metabolic rate, the thermic effect of foodalso referred to as dietary-induced thermogenesisand the energy utilized during physical activity [60, 61]

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2.2 Dysregulation of neurotrophic support Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB), constitute a signaling axis fundamental to neuronal survival, differentiation, and synaptic plasticity within the central nervous system (Numakawa and Kajihara, 2025)