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The company also faced high costs of defending itself from personal injury lawsuits claiming Accutane caused irritable bowel diseases, including Crohns and ulcerative colitis

FDA Fast Track designationU.S.General cancer painPhase 2aCompleteAcute surgical painPreclinical SP16 Intravenous AdministrationSP16 IV / LRP1 agonist / IV peptide therapeutic / Neuropathy / cancer-related painChemotherapy-induced peripheral neuropathy (CIPN)Phase 1bNCI funded / forthcoming IMC-1IMC-1 / Herpesvirus suppression / COX-2 inhibition / Fixed-dose combination of anti-herpesvirus medication and COX-2 inhibitor / Pain / fatigue illnessFibromyalgiaPhase 2aPreviously demonstrated efficacy

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Oral probiotic supplementation with strains like Lactobacillus plantarum has been shown to reduce inflammatory markers including zonulin (a key marker of intestinal permeability), supporting a tighter gut barrier that keeps these compounds where they belong