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The compound demonstrates exceptional target selectivity, with no inhibition of related methyltransferases (DNMT1, PRMT3, COMT) or NAD+ salvage enzymes (NAMPT, SIRT1) at concentrations up to 600 M

As with all the compounds we synthesize, its purity is paramount

In clinical trials, retatrutide has been studied as a once-weekly injection using gradual dose escalation