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MACE includes non-fatal heart attack, non-fatal stroke, or cardiovascular death

GLP-1R regulation of food intake The reduction in body weight induced by GLP-1R agonists is largely attributed to a reduction in food intake

IGF-1 (Insulin-like growth factor-1) is a major hormonal mediator of statural growth

Key takeaways GLP-1 medications do not inherently cause muscle wasting. Most weight lost on semaglutide or tirzepatide is fat , not muscle. Some lean-mass loss during weight loss reflects adaptive remodeling , not pathology. Adequate protein intake and resistance training significantly reduce muscle loss during GLP-1 therapy. Do GLP-1 Medications Cause Muscle Wasting