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Hepatocytes have a reduced capacity to eliminate ammonia through the urea cycle, leading to hyperammonemia that stimulates glutamine synthesis in extrahepatic tissues (muscle, brain, heart, and lungs)

For the CY 2026 OPPS/ASC proposed rule, we estimated the geometric mean cost for CPT code 0421T to be $10,342 based on 7,557 single claims and proposed to assign the service to APC 5376 (Level 6 Urology and Related Services), which has a geometric mean cost of $9,746