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As we age, NAD levels naturally decline, leading to reduced mitochondrial efficiency and increased oxidative stress, which are associated with various age-related diseases and cognitive impairments

UA increases iNOS expression in the -cells, decreases GSIS, and causes apoptosis [39]

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Lysosome-dependent cell death (LCD) is a subroutine of RCD initiated by perturbations in intracellular homeostasis and demarcated by the release of hydrolytic enzymes into the cytosol following lysosomal membrane permeabilization (LMP) [3, 76, 177]