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In experimental systems, DSIP has been shown to influence second messenger activity and hormonal signaling cascades linked to the hypothalamicpituitaryadrenal axis, including regulation of adrenocorticotropic hormone and related endocrine mediators [4]

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Treatment combining with ACTH, antiseizure medications, and vitamin B12 in these patients has shown improvments in EEG features and imaging manifestations, leading to a reduction in seizures