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Based on commercially available analogues a preliminary structureactivity relationship study revealed that substitution of the amino position (R1, R2) showed broad tolerability of aliphatic groups and that lipophilic substituents of the phenyl group at the 3 position (R3) in the ortho and meta positions were well tolerated

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DaboAJEzegbunamWWymanAEMoonJRailwahCLoraAet alTargeting c-Src reverses accelerated GPX-1 mRNA decay in chronic obstructive pulmonary disease airway epithelial cells

Consequently, a reduction in the dosage of metoprolol may be warranted (Shi et al., 2022)