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Common adverse reactions include nausea, belching, acid reflux with heartburn, diarrhea, vomiting, constipation, abdominal discomfort, fatigue, injection site reactions, and hypersensitivity reactions
However, contrasting data from other studies showed that the addition of PDE4i rolipram to standard TB treatment accelerated mortality, increased the bacterial burden, and did not reduce the time to bacterial clearance in the lungs of a mouse model of TB [34], raising concerns about the general applicability of PDE-Is
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