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Two of them have been shown to mediate the post-receptor effects of insulin: myo-inositol (MI-cis-1,2,3,5-trans-4,6-cyclohexanehexol) and D-chiro-inositol (DCI-cis-1,2,4-trans-3,5,6-cyclohexanehexol) (DCI)

They are widely sold online despite limited scientific evidence and should not be considered substitutes for prescription GLP-1 medications

However, these tools are still in the investigational stage, and their transition into clinical practice demands rigorous validation through large-scale, multicenter studies

Because GCLC floxed X Iba1-Cre mice died early (around 34 months of age) due to developmental defects, we could not assess the effect of microglial GCLC-deficiency on brain atrophy