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Only unique reads falling in exon regions were considered, and in cases in which a strand-specific library preparation was used, the reads were counted accordingly

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Another study demonstrated that while branched-chain amino acids (valine, leucine, and isoleucine) and taurine were significantly decreased, three metabolites of the kynurenine pathway, specifically 2-aminobenzoic acid, xanthurenic acid, and hydroxy picolinic acid were reported to be significantly upregulated in ESKD patients compared to CKD patients