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Abstract We developed a novel enzymatic glutathione (GSH) production system using Saccharomyces cerevisiae as a whole-cell biocatalyst, and improved its GSH productivity by metabolic engineering

That same body of work fed into an early-phase human trial registration (NCT02637284) that was later withdrawn before results were reported, which is why anyone telling you BPC-157 is "clinically proven" in humans is overstating the record

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Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]