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G6PD-deficient individuals are also at a high risk of severe hemolysis when given anti-malarial drugs, such as quinine, primaquine or chloroquine, through irreversible oxidative activity of their metabolites on erythrocytes 8,9

89 Conventionally, GDH (coded by the GLUD gene) is the more predominant enzymes vital for the reactions needed to replenish the TCA cycle and yield NADPH than GOT2 and GPT2, which consists of ubiquitously expressed GDH1 and GDH2 mainly existing in neuronal and testicular tissue and having lower activity than GDH1

Competing interests The author declares that there are no competing interests

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