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Potential Side Effects As with any treatment, Semaglutide comes with potential side effects

Clinical studies indicate that cardiomyocytes are particularly vulnerable to free iron overload, and excessive heme iron intake has been linked to an elevated risk of cardiovascular diseases

It also caused less GLP-1R internalization than GLP-1, due to the weaker -arrestin recruitment (30-50% Emax of GLP-1) 30

*Correspondence: Yu Zhou, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers