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Therefore, targeting cellular oxidative stress through antioxidants has been suggested as a potential therapeutic option against neurological disorders, particularly using natural plant extracts

The vasoprotective effects are most evident in models of diabetic retinopathy, where a hallmark of the disease is the breakdown of the BRB and subsequent retinal vascular leakage [61]

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Approaches to overcome this challenge include design of microfluidic devices with precisely controlled oxygen gradients, incorporating nanoporous membranes separating microbial and host cells while permitting molecular exchange