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Strategy 7: Gentle desensitization Deliberately exposing sensitive skin to controlled, gentle stimulation can help recalibrate nerve responses

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P = .18) or new-onset DME (7390 [22.6%] vs 7425 [22.7%] events

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These metabolites can regulate the expression of genes involved in drug metabolism and detoxification, illustrating the intricate relationships among the gut microbiota, liver function, and drug metabolism (13)

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If tirzepatide appears ineffective after an adequate trial period, systematic evaluation should precede any treatment changes

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