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6 While many of these agents, such as RAAS blockers, effectively attenuate adverse general cardiac remodeling and improve survival by targeting specific signaling pathways, significant gaps remain in addressing key disease-driving mechanisms, such as chronic inflammation, fibrosis, and metabolic dysregulation

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PARPs, located in the nucleus, mediate many biological processes, including DNA repair, transcriptional regulation, and metabolism (41, 45), by transferring long chains and branches of ADP-ribosyl polymers to their protein substrates