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In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 g vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)

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When 5-amino-1MQ increases cellular NAD+ levels, it enhances mitochondrial function, the powerhouses responsible for converting nutrients into usable cellular energy

Interestingly, in humans with B12 deficiency then, that's also been associated with dementia, which might explain why Elizabeth cat was constantly crying and vocalizing