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Nature Communications, 9, 113

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Studies have shown that metformin has a modulating effect on the composition and function of the intestinal microbiota other than acting on the liver

Semaglutide for Weight Loss: What the SURMOUNT-5 Results Mean for Northwest Louisiana Patients For the first time, a major clinical trial put tirzepatide (Mounjaro/Zepbound) and semaglutide (Ozempic/Wegovy) head to head in people with obesity who do not have diabetes, and the results landed in the New England Journal of Medicine in May 2025.[1] The short answer: tirzepatide produced significantly more weight loss